ELISA kit for Chicken Transforming growth factor Beta2 (TGF-Beta2)

Допълнителна информация

TGF-?2 encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes TGF-?2 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in TGF-?2 may be associated with Loeys-Dietz syndrome. TGF-?2 encodes multiple isoforms that may undergo similar proteolytic processing.